The organochlorine xenoestrogens may produce this effect following binding to a hormone receptor (with or without metabolic activation) or by affecting the 17 beta-estradiol pathways leading to increased formation of more potent estrogenic metabolites. ![]() It has been hypothesized that these compounds, among others, may be associated with increased incidence of breast cancer and other estrogen-related cancers in women due to increased proliferation of breast epithelial cells. Recently, debate has increased concerning endocrine disrupting activity of these compounds and especially their ability to produce biologic responses comparable to those of endogenous estrogens (e.g., 17 beta-estradiol). ![]() Compounds meeting these criteria include above all a large group of persistent organochlorine compounds. Many of these pollutants feature such unwelcome characteristics as: persistence in different environmental media, ability to bioaccumulate and biomagnify in individual food chains, as well as ability to undergo long-range atmospheric transport. The presence of many chemical pollutants in the environment and their potential impact to human health creates rather justified anxiety.
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